欧盟评估一种三酰甘油脂肪酶的安全性

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    2023年1月18日，欧盟食品安全局就一种食品酶三酰甘油脂肪酶（triacylglycerol lipase）的安全性评价发布意见。

据了解，这种食品酶是由非转基因少根根霉菌株AE-N生产的，旨在用于通过酯交换生产改性脂肪和油的过程中。

经过评估，专家小组认为，在预期的使用条件下，不能排除通过饮食接触引起过敏反应的风险，但这种情况发生的可能性很低。根据所提供的数据，小组得出结论，该食品酶在预期的使用条件下不会引起安全问题。部分原文报道如下：

The food enzyme triacylglycerol lipase (EC 3.1.1.3) is produced with the non-genetically modified Rhizopus arrhizus strain AE-N by Amano Enzyme Inc. It is considered free from viable cells of the production organism. The food enzyme is intended to be used in an immobilised form in the modification of fats and oils by interesterification. Since residual amounts of total organic solids (TOS) are removed during refinement of the fats and oils, dietary exposure was not calculated. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,806 mg TOS/kg body weight (bw) per day, the highest dose tested. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

关键词： 三酰甘油 安全问题 的可能性